Brain Tumors Could be Fought by Engineered Form of the Polio Virus
Under an investigational therapy known as PVSRIPO, the researchers at Duke Cancer Institute said that modified form of polio virus holds potential to fight the brain tumors.
The scientists who conducted the research said that the modified virus did not pose any threat to the normal cells but targets the cancer cells. It has capability to fight the most common and aggressive form of brain tumor called glioblastoma.
In a news release, Dr. Annick Desjardins, the Principal Investigator and an Associate Professor of medicine at Duke University School of Medicine, said that the findings of the study were quite fascinating.
He asserted that the existing therapies for treatment of glioblastoma are restricted since they are unable to target the tumor, being not able to cross the blood-brain barrier. However, the newly discovered treatment seems to overcome these barriers.
The therapy is based in the fact that the cancer cells' receptors attract polio virus. The modified polio virus works by infecting and killing the tumor cells. Further, the research averred that the therapy also triggers the immune system to target the infected the tumor cells.
The findings of the study are expected to be presented at the American Society of Clinical Oncology annual meeting in Chicago, which is to be held from May 31 to June 4.
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